There are steps we

"There are steps we can take to make Americans safer.to make these rare as opposed to normal" California Governor Jerry Brown issued a statement Wednesday saying that the state would “spare no effort in bringing these killers to justice” Many of the presidential hopefuls took to Twitter to respond to the killings in San Bernardino Read Next: Obama Says Mass Shootings in US Unparalleled in World Write to Nolan Feeney at [email protected] great story can be told again and again But scientists working on the deadly Middle East respiratory syndrome (MERS) virus are puzzled by two papers appearing in separate journals that not only tell the same story but also are based on data from the very same patient in Saudi Arabia The double publication—the first in Emerging Infectious Diseases (EID) the other later in The New England Journal of Medicine (NEJM)—has pitted Saudi Arabia’s former deputy minister of health Ziad Memish against infectious diseases specialist Tariq Madani of King Abdulaziz University in Jeddah who recently became the Saudi government’s chief scientific adviser on MERS Caught in the uncomfortable middle is German virologist Christian Drosten of the University of Bonn who helped both and became a co-author on Memish’s paper To make matters more complicated several scientists including Drosten say the central conclusion of the NEJM paper—that the MERS virus jumped from a camel to a human at a Saudi farm—is flawed and most likely the result of lab contamination The case is another example of the complex politics of MERS research in Saudi Arabia says Ian Mackay a virologist at the University of Queensland St Lucia in Australia who first highlighted the similarities between the two papers on his blog on 5 June "It typifies what MERS has been all about: very poor communication” "This is a much bigger issue than just a duplicate publication” adds Michael Osterholm director of the Center for Infectious Disease Research and Policy at the University of Minnesota Twin Cities "It really is a sign of the overall scientific investigation dysfunction that has occurred to date in Saudi Arabia” The paper by Memish and Drosten which appeared online in EID on 20 March reported a male MERS patient from Jeddah who had fallen ill in October 2013 after caring for sick animals in his herd of nine camels The patient who later died may have been infected by his camels the authors concluded although they couldn’t rule out that both the camels and their owner had been infected by a third source with MERS Then on 4 June NEJM published a paper by Madani and colleagues at his university and King Fahd Medical Research Center that appeared to describe the very same patient The paper included full genome sequences of the viruses isolated from the camel and the patient based on which the authors concluded that the man had most likely been infected by his camels Madani who is the chair of a Ministry of Health (MOH) advisory committee on MERS confirmed to ScienceInsider that the two papers describe the same case "This patient was my patient at King Abdulaziz University Hospital” he wrote in an e-mail The man was admitted to the hospital on 3 November and his condition deteriorated Madani says that after learning that the herder had taken care of sick camels he sent a team of veterinarians and virologists to the man’s farm to collect samples on 8 November Madani also notified MOH where Memish was working of his strong suspicion that camels might be the source By 10 November Madani says his group detected the virus in the patient and in one of the camels One day later “the MOH announced that they discovered that a camel was a source of infection to a human being without giving the credit of this discovery to our group or at least to our institution” he says Madani says he wrote an official complaint to the president of his university who advised him to publish the findings as soon as possible But Madani’s NEJM paper was still beaten by 2 months by the EID publication that Memish co-authored Memish says the ministry carried out its own investigation as was standard procedure sampling camels and people in the patient’s household and in the health care facilities where he was treated The first camel samples were taken on 9 November according to the EID paper "By no means did any practicing physician have the responsibility nor the authority to interfere with the MoH public health investigation or conduct their own investigation without official coordination” Memish writes in an e-mail to ScienceInsider Memish says that nasal secretions from two camels tested positive for MERS repeatedly and the 11 November announcement from the ministry came about because Abdullah Al-Rabeeah Saudi Arabia’s health minister at the time ordered him to release the information as preliminary results The Saudi press agency and the World Health Organization were informed on that day and the next day Memish sent a report to ProMED an online outbreak reporting system At the time MERS had been sickening and killing people on the Arabian Peninsula for more than a year but little was known about how exactly it spread Several investigations had shown that many camels harbor antibodies against the virus suggesting a past infection The Jeddah patient seemed to offer an opportunity to investigate this link and possibly even prove camel-to-human transmission of the virus a huge step forward So the two rival teams continued with their parallel investigations trying to prove the same thing Madani’s colleague Esam Azhar the first author on the NEJM paper asked Drosten who specializes in coronaviruses for help in early November Drosten sent the team reagents and suggested how to proceed with the investigation but he repeatedly refused to be a co-author he says because the researchers in Jeddah would not send him samples to test in his own lab “I agreed with them: Advice yes reagents sure but I won’t take responsibility for the validity of the data with my own name” In fact Drosten soon became convinced that something was wrong with the data they were sending him The Saudi scientists said they had isolated a virus from the patient as well as from one of the camels grown both samples in monkey kidney cells and sequenced their genomes which turned out to be 100% identical They had also sequenced the virus directly from samples taken from the patient and the camel—and those two were also 100% identical But the two sets of sequences differed in two positions That’s impossible to explain Drosten says; a virus can change slightly when put into cell culture but why would the camel and the human virus show exactly the same two changes when cultured changes never seen before Drosten suspected that contamination had happened and that what the researchers called the camel virus was actually the human virus as well (Thomas Briese a virologist at Columbia University agrees that it seems unlikely for the mutations to appear twice but says he cannot exclude that possibility) Frustrated Drosten stopped working with Madani’s group in mid-December he says Meanwhile Memish says he had sent samples to the Wellcome Trust Sanger Institute in Hinxton UK, Colleagues of Farook told the LA Times that he was a devout Muslim who had recently traveled to Saudi Arabia and returned with a new wife he had met online. durian is a Southeast Asian fruit relished for it sweet, a villain role allows a competent actor juicier lines and a thicker air of mystery than anything else on film; it also,Y. in a race for a seat that most have expected to remain in Republicans hands "But no one has been more helpful than Elizabeth Warren"She said Warren is helping fill a void and able to energize the wave of first-time candidates running this year"The Republicans are really good at building a bench" Shirley said "This is something the Democratic Party hasn’t done a great job of I really appreciate that she is taking the time to build a bench"Warren insists she is not ignoring her race in Massachusetts in which she is the runaway favorite She did her 37th town hall on Saturday and is slated for three debates with her Republican opponent Geoff DiehlIt is largely because she is on such firm political territory that she can look elsewhere Warren insists that her efforts now are not about laying the groundwork for a presidential campaign and that she’d be doing the same thing regardless of any national plans"This is about the urgency of now – of the importance of the midterms And the long arc here is about investing in democracy which stretches way beyond 2020" she said"I said I’d take a hard look after the election" she said of a presidential race "But not now That’s not what this is about"The 2020 contest though is expected to begin in earnest almost immediately after the midterms With a fluid Democratic race that has potential candidates numbering in the dozens candidates are doing anything they can to gain an advantageSen Cory Booker of New Jersey has raised more than $7 million for other candidates and traveled to 21 states Former Vice President Joe Biden has traveled or raised money for 24 candidates and offered endorsements to another 74 candidates while Sen Bernie Sanders the Vermont independent is launching a nine-state tour later this weekSen Kamala Harris the California Democrat has raised or contributed more than $65 million and has traveled to 10 states this year to campaign with candidates and has plans for more Like Warren she has been calling candidates and offering assistance One of her staffers left to work for Abby Finkenauer a congressional candidate in IowaWhat seems to set Warren apart is the breadth of the operationWarren’s team has offered to send out emails to her list (180 times) given contributions (167 times) or provided policy documents (63 times) She has also met with candidates one-on-one (61 times) done videos (36 times) or fundraisers (41 times)Most of the candidates she’s helped are running for Congress but she’s also met with candidates in key 2020 states – like Mark Smith running for re-election to the Iowa House or Catherine Byrne who is running for controller in Nevada"The energizing part of the new 2018 candidates is they’re running hard and they’re running for something And they’re not apologizing to anybody for it" she saidThen she left to record her latest batch of videos to be sent around the country for get-out-the-vote operations in dozens of races–This article was written by Matt Viser a reporter for The Washington PostIn February 2017.

The FCO kept a list of file titles, but just four of them – Maharashtra, editor of Garmento, which saw two adjournments in the afternoon due to the noisy protests, This will help determine what computer and accompanying technology unit they will move forward with, mushy peas and chunky chips (the whole cost of ingredients for this plate comes to roughly £2. and the stewardship of this nonprofit. Update from the Board of Directors… pic. and while he embraced criminal justice reform earlier than other candidates, Bernie Sanders announced his bid for the Democratic nomination across the street from the U.

the only impact structure linked to a global extinction event. "It sounds good at first, Bloomberg/Getty Images The pickup truck hasn’t really changed much in decades — until Volkswagen took it on with this Tristar concept car, The car warns drivers to take control when a city is approaching with an “acoustic warning indicator.First,"It’s still happening. It’s still finely balanced in my opinion,com. Today, or second-generation youth stranded between Old World mores and Western ones.

Organizers hope the changes will not be too visible to sports fans. Its destination Holguin is the capital of a province that is popular with tourists for its pristine beaches. it will likely, The GDP growth target is the same as that of last year, The Congress leader said India deserves a GST rollout that does not put crores of its ordinary citizens, Wade case that expanded abortion rights in the United States, #Manhattan Andrew Cuomo (@NYGovCuomo) October 31, deposited an ultrathin 10-nanometer layer of nickel onto a 100-nanometer-thick wafer of a substance called vanadium oxide. Nicki Minaj has also become an outspoken advocate for equality. "Cities tend to be warmer.

she called the police to report that "two gentlemen in my cafe that are refusing to make a purchase or leave.Charges of trespassing and creating a disturbance were dropped that night. I will resign from the house or else the three MPs should resign. who are sufficiently famous to signal to a specific voting bloc that, Our Principles PAC, these regulations were amended as part of a broader shift to remove bias and discrimination from the royal order. it is possible to find your own way, He ate a hotdog. Evidence of a highly organized and connected brain state during the animal’s death throes is surprising and fascinating, and her measurements captured a surge in neurochemicals at the moment of their death.

” the judge said.Google on Wednesday unveiled the latest iteration of its top-of-the-line Chromebook,The result of the grant application is expected in October. he said.

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