Rai P, Padala C, Poon V, et al. Statistical pattern matching facilitates the design of polyvalent inhibitors of anthrax and cholera toxins. Nature Biotech 2006 Apr 23 (early online publication) [Full text] Apr 24 NIH news releasehttp://www.niaid.nih.gov/news/newsreleases/2006/Pages/AMD_06.aspx In test-tube experiments, the antitoxin was 10,000 times more potent than single peptides, the NIH said. The NIH-supported research was done by a team led by Ravi S. Kane, PhD, of Rensselaer Polytechnic Institute in Troy, N.Y., and Jeremy Mogridge, PhD, of the University of Toronto. Their report was published Apr 23 in Nature Biotechnology. See also: The PA molecule has a number of sites that can bind to host cells, the NIH said. Therefore, Kane and colleagues created a molecule that can cling to PA at multiple sites. The protein-studded bubble they produced is called a peptide-functionalized liposome. “Just as a glove matches the shape of a hand more closely than a mitten, and so fits more snugly, the polyvalent inhibitor binds the toxin at multiple sites and is orders of magnitude more potent than an inhibitor that binds at a single site,” the agency said. “The multiple peptides on the functionalized liposome are arranged with the same average spacing as the binding sites of the PA molecule, which permits a firmer bond between the two, explains Dr Kane.” The researchers created a fatty bubble, studded with proteins, that binds to a key component of anthrax toxin at multiple sites, preventing it from attaching to host cells, the National Institutes of Health (NIH) said in a news release. “This novel approach to the design of anthrax antitoxin is an important advance, not only for the value it may have in anthrax treatment, but also because this technique could be used to design better therapies for cholera and other diseases,” said NIH Director Elias A. Zerhouni, MD. The investigators used the same liposome-based technique to develop a polyvalent inhibitor of cholera toxin, which also worked well in test-tube experiments, the NIH said. As explained in the NIH release, the toxin produced by Bacillus anthracis has three parts: a protein called protective antigen (PA), which binds to receptors on target cell surfaces, and two enzymes. When PA binds to a host cell, it creates a pore that enables the enzymes to enter the cell. Apr 25, 2006 (CIDRAP News) Scientists have come up with a new approach to neutralizing the toxin produced by anthrax bacteria and have tested it successfully in a small number of animals, according to a report published this week. The antitoxin was also tested in rats. When nine rats were simultaneously injected with anthrax toxin and relatively small doses of the new antitoxin, five of them remained healthy. When slightly higher doses of the inhibitor were used, eight of nine rats were protected. The journal article says the experiment was the first to show that a liposome-based polyvalent inhibitor works in animals. The team next plans to infect animals with B anthracis and allow the disease process to begin before treating them with the anthrax antitoxin, the agency said.
By the way, the exact number of renters who have used HBOR’s credit line so far is a business secret, but as we unofficially find out, a total of about 50 renters used this credit line to finance the work of private renters. More on that in the attachment. Source: Novi List / Cover photo: Apartment Pinja, Cres / Booking.com An education in tourism was held on the island of Cres so that Cres renters could better prepare for the upcoming season and new tourist trends, which are jointly organized by the Cres Tourist Board and the Cres Landlords Association. Namely, it is HBOR’s credit line for renters, in which the Ministry of Tourism subsidizes one percentage point of interest, so that renters can get a loan with an interest rate of two percent per year and a one-year grace period. However, according to the proposal of the mayor of Cres, the city would join this credit line and subsidize the remaining two percent, which would make loans for Cres renters interest-free. Vesna Bartolović, head of HBOR’s regional office for Primorje and Gorski kotar, who presented the new credit line of the Croatian Bank for Reconstruction and Development, Renato Kraljev, a well-known Croatian chef, spoke about the formation of menus based on indigenous dishes and groceries and Nedo Pinezić, the first man of family accommodation in Croatia. RELATED NEWS: HOW MANY RENTERS HAVE USED THE CREDIT LINE TO FINANCE THE WORK OF PRIVATE RENTERS? The news that resonated from the workshop was the proposal of the mayor of Cres, Kristijan Jurjak, to include Cres with a subsidy for loans to renters, which would provide Cres renters with interest-free loans to raise the quality of accommodation, writes Novi List.
Topics : Hong Kong’s flagship English-language newspaper, the South China Morning Post, owned by Alibaba Group Holding Ltd, will cut senior management pay and ask staff to take unpaid leave for three weeks, a staff letter obtained by Reuters showed.Chief executive Gary Liu said in the letter the cost cuts were needed because of a 20% fall in revenues in the 2019/20 financial year and a 50% drop in the latest quarter despite more readers amid last year’s protests and the coronavirus outbreak.Liu said “limited” layoffs would take place, salaries would be frozen and he was cutting “almost everything that can be spared” on operations from non-essential travel to the annual company party. “SCMP’s journalists have withstood tear gas, petrol bombs, dangerous confrontations, and exposure to deadly disease, not to mention the countless hours spent pursuing stories that have powered our growth,” Liu said.”But even with resolve and immense audience growth, SCMP’s revenues declined,” he said, adding that the newspaper was heavily reliant on the recession-hit Hong Kong economy.The newspaper reported that the pay of senior management would be cut and staff would be put on unpaid leave. It did not immediately respond to a request for comment on Liu’s letter.From Rupert Murdoch’s News UK to McClatchy’s chain of newspapers across the United States, news publishers are attracting record numbers of readers as people in lockdown seek information, yet advertising revenue has plummeted.The Hong Kong newspaper, which is more than 116 year old, was taken over by Alibaba from Malaysian tycoon Robert Kuok in a $266 million deal in 2015.
NewsTalk ZB 9 May 2016Family First Comment: And legalising euthanasia would simply make it worse.We’re being told not to forget about the older community in a bid to prevent elderly suicide.Elderly suicide is set to be discussed at a mental health conference attended by psychiatrists from New Zealand and Australia today.Spokesperson for counselling service Relationship Matters Steve Taylor said elderly people often go into care and get visits from family once every couple of weeks.He said this can make them feel lonely, helpless and without purpose.“The more that a person loses their sense of hope and purpose then the less will they have to actually be able to contribute or go on living.”He said when people grow older some people assume they don’t have much use anymore.“They have a lot to contribute, particularly to the younger generation, and I think one of the key things we could do is have a situation where we could actually talk to a lot of people and say what is it that you would like to offer, what is that you would like to contribute and how can we help you do that.”READ MORE: http://www.newstalkzb.co.nz/news/national/elderly-suicide-on-metal-health-conference-agenda/
Barcelona new signing PaulinhoBarcelona, Spain | AFP | Barcelona made Brazilian international midfielder Paulinho their first signing since banking a world record fee for Neymar on Monday after agreeing a 40 million-euro ($47 million) fee with Chinese club Guangzhou Evergrande.“Barcelona and Guangzhou Evergrande have reached an agreement for the transfer of the player Paulinho Bezerra for 40 million euros,” Barca said in a statement.The 29-year-old has signed a four-year deal with a 120 million-euro buyout clause and will be formally presented on Thursday.The announcement of Barca’s third signing of the summer transfer window after Gerard Deulofeu and Nelson Semedo came just hours after the Catalans suffered a 3-1 home defeat to Real Madrid in the Spanish Super Cup first leg on Sunday.Midfielder Sergio Busquets had put pressure on the club’s board by claiming Barca had to strengthen their squad before the transfer window closes on August 31.Barca have so far been unsuccessful in their attempts to land a more natural replacement for Neymar with huge bids for Philippe Coutinho and Ousmane Dembele being rejected by Liverpool and Borussia Dortmund respectively.“I hope you are as happy as I was there,” Neymar wrote on Instagram to wish his international teammate well.However, Paulinho’s arrival has not been warmly received by the Barca fanbase.Over 80 percent of fans urged the club not to sign him for over 20 million euros in a survey conducted by Barcelona sports daily Mundo Deportivo. That lack of enthusiasm is due to Paulinho’s chequered career at club level in Europe.After spells in Lithuania and Poland as a teenager, Paulinho moved to Tottenham Hotspur from Corinthians in 2013.Yet he failed to shine in two years in England before moving to Guangzhou in 2015 for 14 million euros.However, he has rebuilt his career in China and established himself as a regular in a rejuvenated Brazil side since the appointment of Tite as coach a year ago, most notably scoring a hat-trick in a 4-1 win away to Uruguay in World Cup qualifying back in March.And Paulinho’s former coach at Tottenham, Andre Villas-Boas, believes his move to Barca is a huge boost for the prestige of the Chinese Super League.“Because Paulinho’s come here, he’s done ever so well and now he has a transfer to one of the biggest clubs in the world,” said Shanghai SIPG coach Villas-Boas.“I think it shows that the big clubs are also looking at our league. It’s a reflection of the players and the quality of work that is being done here.”Share on: WhatsApp