Rai P, Padala C, Poon V, et al. Statistical pattern matching facilitates the design of polyvalent inhibitors of anthrax and cholera toxins. Nature Biotech 2006 Apr 23 (early online publication) [Full text] Apr 24 NIH news releasehttp://www.niaid.nih.gov/news/newsreleases/2006/Pages/AMD_06.aspx In test-tube experiments, the antitoxin was 10,000 times more potent than single peptides, the NIH said. The NIH-supported research was done by a team led by Ravi S. Kane, PhD, of Rensselaer Polytechnic Institute in Troy, N.Y., and Jeremy Mogridge, PhD, of the University of Toronto. Their report was published Apr 23 in Nature Biotechnology. See also: The PA molecule has a number of sites that can bind to host cells, the NIH said. Therefore, Kane and colleagues created a molecule that can cling to PA at multiple sites. The protein-studded bubble they produced is called a peptide-functionalized liposome. “Just as a glove matches the shape of a hand more closely than a mitten, and so fits more snugly, the polyvalent inhibitor binds the toxin at multiple sites and is orders of magnitude more potent than an inhibitor that binds at a single site,” the agency said. “The multiple peptides on the functionalized liposome are arranged with the same average spacing as the binding sites of the PA molecule, which permits a firmer bond between the two, explains Dr Kane.” The researchers created a fatty bubble, studded with proteins, that binds to a key component of anthrax toxin at multiple sites, preventing it from attaching to host cells, the National Institutes of Health (NIH) said in a news release. “This novel approach to the design of anthrax antitoxin is an important advance, not only for the value it may have in anthrax treatment, but also because this technique could be used to design better therapies for cholera and other diseases,” said NIH Director Elias A. Zerhouni, MD. The investigators used the same liposome-based technique to develop a polyvalent inhibitor of cholera toxin, which also worked well in test-tube experiments, the NIH said. As explained in the NIH release, the toxin produced by Bacillus anthracis has three parts: a protein called protective antigen (PA), which binds to receptors on target cell surfaces, and two enzymes. When PA binds to a host cell, it creates a pore that enables the enzymes to enter the cell. Apr 25, 2006 (CIDRAP News) Scientists have come up with a new approach to neutralizing the toxin produced by anthrax bacteria and have tested it successfully in a small number of animals, according to a report published this week. The antitoxin was also tested in rats. When nine rats were simultaneously injected with anthrax toxin and relatively small doses of the new antitoxin, five of them remained healthy. When slightly higher doses of the inhibitor were used, eight of nine rats were protected. The journal article says the experiment was the first to show that a liposome-based polyvalent inhibitor works in animals. The team next plans to infect animals with B anthracis and allow the disease process to begin before treating them with the anthrax antitoxin, the agency said.
9 Derby Street, Hendra is an absolute crackerThe stunning two-level home has five-bedroom, four-bathroom accommodation suited to a high-end owner who’s ready to revel in the good life.More from newsMould, age, not enough to stop 17 bidders fighting for this home1 hour agoBuyers ‘crazy’ not to take govt freebies, says 28-yr-old investor1 hour agoThe finish throughout is stunningIt’s the architectural finish of the 467sq m structure that’s sure to catch the eye, according to Ray White Ascot marketing consultant, Leigh Kortlang.“The centrepiece of the house, a soaring six metre ‘breeze-corridor’ brings an abundance of uninterrupted North-Easterly sunlight and cool Moreton Bay breezes into all corners of the house,” she said.For the host/hostess with the mostest, there’s an entertainment ‘hub’ with media den and kitchenette, as well as an envy-inducing pool area that will happily host a riot of revellers. Soaring ceilings and open plan design are all featuresFollow Kieran Clair on Twitter at @kieranclair or Facebook on Kieran Clair — journo A great place for guests to gatherBut it’s the ensuite that might cause a stir among more modest buyers.“The main suite is the ultimate parent’s haven; including a stunning ‘open-plan’ bathroom, ‘his and hers’ vanity and showers, walk in robe and a private balcony,” said Ms Kortlang.The beautiful freestanding bath is positioned next to the large balcony door so you will certainly feel the breeze and catch a view after stepping from a soak. This architectural home features high-end finishes and an open plan ensuite – no more knocking on the door to check whose in the tub.ARE you the shy retiring type, or do you prefer to telegraph success? 9 Derby St, Hendra is up for auction Saturday September 9, and the new owner will need to be a bit of an extrovert — particularly if they plan to take a bath. Hello sunshine! A tub with a viewAnd the early-morning commute time will be reduced by the short three-step stroll from bed to tub. $1.48M UNIT WITH SHOWER NEXT TO BED
Ireland’s actuaries are recommending that the government make private pensions mandatory for all workers, rather than introduce a UK-style system of automatic enrolment. The Society of Actuaries in Ireland said a compulsory pension system should be developed over the next five years as a way of increasing pensions coverage and making sure individuals have enough in retirement. Bringing in auto-enrolment is potentially wasteful, if the government later goes down the mandatory route anyway, it said. The recommendation is among the conclusions from a working party on pensions policy set up by the society in March 2013. The aim was to join the debate on whether a mandatory system was better than other methods, such as auto-enrolment, to complement the state pension. The society said it knew auto-enrolment might seem more palatable than a mandatory system in the current economic environment in Ireland. “However, in our view, a mandatory system is superior to an auto-enrolment regime for a number of reasons,” it said. A mandatory regime was a more effective way of increasing private pensions coverage than auto-enrolment, it said, citing international experience. Also, a mandatory system should be easier to run since there will be no opt-out and opt-in issues, it said. “Establishing the more complex system of auto-enrolment and subsequently introducing the mandatory regime could potentially be a waste of resources,” it added. Because it would take at least five years to bring a mandatory scheme into operation, the society said there was a need to move ahead quickly with decision-making and planning. Last April, the Organisation for Economic Co-operation and Development (OECD) said in a review of Ireland’s pension system that making it compulsory for private workers to establish a pension was the cheapest and most effective approach to increasing coverage of private pensions. It said Ireland and New Zealand were the only OECD countries that did not have a mandatory earnings-related pillar to complement the state pension at basic level.
Troutman, BrentonMoore, MariahStone, ElishaScott, Max Superintendent Honor Roll – SeniorsSuperintendent Honor Roll – JuniorsSuperintendent Honor Roll-SophomoresSuperintendent Honor Roll-Freshman 4.00 GPA4.00 GPA4.00 GPA4.00 GPA Crittenden, ChaseDeJarnett, BayleeElix, NathanBrownlee, Elizabeth McCracken, KirstanHaskins, TatumMartens, DevinKing, Ian Daily, WilliamJohnson, DaMoggioSchoemann, Aaron Driskell, WestonOldridge, BryceOwston, HunterWilson, Ty Luna, Jonah Steinbach, Drake Reichenberger, ColinTidwell, StormiePalmer, Liberty 3.0-3.499 GPAFarley, HaleyLangford, ReeceSnipes, Antoine Vargas, DominiqueFarley, JacobRusk, Avery Nelson, Riley Close Forgot password? Please put in your email: Send me my password! 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Tweet this comment Cancel Submit Comment Subscribe to None Replies All new comments Peck, JuliaLuna, JaylynnLeGrand, CarsonLowe, Abigail Chandler, LupitaPrincipal’s Honor Roll-JuniorsBurnett, ConnorCary,Trey Easterly, Candyce Tidwell, SkylarMcNamara, ShelbyReichenberger, KathrynnRausch, Jenna Cartensen, BenteBlackBull, RaevenBruns, Kirstian Roe, CabrielWalker, SiarahDriskell, DerekRademacher, Avery Nance, TrevorOleson, AlexisRains, CoewenMaxwell, Zoey Follow us on Twitter. Lee, AbigailWilson, RebeccaCreamer, Catherine Staggs, Nicole Reynolds, Courtney Prickett, Kayla Altendorf, TaylorShapley, Faith3.5-3.999 Vargas, AlejandroZimmerman, TaylorFair, KalynRobbins, Shelby Schmidt, Daniel Scholastic Honor RollDeJarnett, GraysenKop, ChristopherSears, Austin Brownlee, DonaldWright, NoelleBernd, TrevorBales, Blake Beard, LaneMcRoberts, SkylaMigues, KatelynTeague, Kaysee Nance, Coby Lira, Samantha Beard, LeviNichols, KyleMontenegro, ElizabethTidwell, Malachi Crowe, AustinAntoine, SaraChalmers, NichlasClayton Hyer, John Nefzger, AustinJones, DylanKimball, LakenLeValley, Kialee Shore, CajenMason, AareonLong, WilliamMcGlothlin, Taylor Hardy, HayleyBucher, TeaganFlores, BeatrizGustason, Shilynn Haydon, JosephCallaway, MirandaFrame, TherinHain, Steven Adams, PeytonAdams, MadisonBarker, MalloryAdams, Jaden Ast, VincentHays, JacobMason, MatthewSparks, Ashlyn McCarty, Meghan Terry, Matthew Templeton, ShaynaMcCue, AllisonMichaelis, JacobRamirez, Hudson Altendorf, BaileyBuck, RyleighBrand, KaymanAdams, Mekenna Dry, JadeGilmore, WesleyFarley, AlishaCunningham, Keelie Coulter, Trey3.5-3.999Byers, KylieClark, Andrew Mohammed, AhmedLeverich, JacobPatterson, KailynLyne, Moriah May, HollieHughes, ShaneHaydon, KelsieJones, Logan Parsons, AlexandriaRusk, CadenSinnett, MatthewMichaelis, Jaden Williams, CaitlinNi, RongWestmoreland, PeightonTempleton, Emily Pfalzgraf, AustinSanchez, CameronSnipes, LaurynNorris, Braedon Pape, KatieLedbetter, KaitlynLawrence, BreckenLove, Adaysia West, Jessica Hughes, TyannaThomas, CadyAraujo, Deyton Kerschen, KadeCook, JacobHilt, AdamJones, Stormie Emberson, Bethany Pruitt, Mariah Bradbury, MikalaCornejo, JulianBristow, StephanieBaker, Hayden Biddle, EmileighSober, DietraArebalo, AshlynPrincipal’s Honor Roll-Freshman Pinkerton, RebeccaLyles, MorganLewellen, MadisonMcComb, Matthew Oathout, McKennaWilliams, AuniTroutman, Arlis Estes, MichelleBartelson, CameronDycus, JadenDry, Andria Morgan, Brayden Luna, Courtney Warner, Bradley Kemper, ChariceVargas, DevinCook, Billy Mitchell, AiyanaHyde, NicholasMatlock, DavidLeonard, Chaney Fike, LindyBaum, EmilyEvans, HannahGageby, Chelsea Brown, OrianWitham, PeytonBarron, MadisonAst, Valerie Crispen, ChristianaNorris, JasonNeal, LeanneWiley, Jillian Overfelt, CourtneyRoths, HannahSchettler, JayceeMcCarty, Emma Nelson, LeahQuanz, JoshuaRoth LindsayMay, MaKenna Lee, JonathanWiseman, ArielCrispen, Evan Bodkins, ZacharyNorland, RandyMoore, AlyssaTurner, Breanna Reyes, JessicaVazquez-Maristany, MercedesScholastic Honor Roll – SophomoresPhelps, Cade Dean, ElizabethGilkey, RemingtonEwing, AshleyBuresh, Briaden Fink, MaggieGoodrum, AbbyGoodrum, ErinDeJarnett, Annika Prickett, TaylorShields, JaredTredway, JoannaOathout, Jared Frederick, ZacharyRodriquez, VanessaPourner, Regan Byers, JoeyYbarra, NateBillington, MichaelBrown, Madison Moore, Victoria Smith, Gabriel Riggs, JacobWager, Jasmine3.0-3.499Â GPAPourner, Chandra Patterson, Tara French, Shayland Horn, WilliamTunnell, EthanSoles, Ashley3.0-3.499 Hardin, Alexander Hines, JadenCaudillo, JozieHain, MorganHinman, James Lloyd, JarynDunnavent, CheyenneKing, JaydenKemper, Kellie Fair, AaronRobbins, KyleParolan, LonidaWolf, Andrew Mayo, Drew Johnson, Andrew Kegley, Chelsea Sanders, Dakota Heller, LeeAnnThompson, DylanShriver, DemiScholastic Honor – Freshman Stafford, Chloe Lee, SarahHollman, PatrickHarriger, CassidyGroom, Ian Brand, SkylarDeJarnett, AddysonEdwards, BrockBlack, Marisa Miller, Kelsey Wright, Shelbie3.0-3.499 GPAHamel, ChaeseSantana, Elizabeth Principal’s Honor Roll – SeniorsPhelps, ConnorWalton, Jack Jackson, AlyssaChandler, JuanHills, KiraJackson, Braydon Pettigrew, Jacob Submitted to Sumner Newscow â€” The following are the Wellington High School Superintendent and Principal’s Honor Roll for the first semester:Â Krueger, KindylHinman, AlexisHadipour, IanFink, Mary Redford, AaronSpears, CharlesWinger, VictoriaOleson, Brandon Lewallen, Joey 3.5-3.999Rosenthal, MikaylaPrincipal’s Honor Roll-SophomoresYoung, Adrianna Diver, AmyBarry, KimberlyCook, KennedyDouglas, Carley Heimer, Jack Bowman, MacyStruble, SkylerBannister, Callie3.5-3.999 Whitney, TrevorScholastic Honor Roll-JuniorsFrench, TaylandSaffell, Alexis Ryberg, JonathanWalton, JakeEtter, HunterReynolds, Derek